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Cytokeratin HMW (Cytokeratin 903), Clone 34bE12, 10mL

SKU #: MM46-10
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Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. Cytokeratin HMW is a high molecular weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins that are found in complex epithelia and shows no reactivity with cells derived from simple epithelia. Cytokeratin HMW can be useful in distinguishing prostatic adenocarcinoma from hyperplasia of the prostate. It has also been useful in separating benign from malignant intraductal breast proliferations. References 1. Gown, AM et al. Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am J Pathol 1984; 114:309. 2. 2. O’Malley, FP et al. Usefulness of immunoperoxidase staining with high-molecular-weight cytokeratin in the differential diagnosis of small-acinar lesions of the prostate gland. Virch Arch A 1990; 417:191. 3. 3. Amin, MB. Analysis of cribriform morphology in prostatic neoplasia using antibody to high-molecular-weight cytokeratins. Arch Pathol Lab Med March 1994; 118:260-264. 4. 4. Wojno, KJ et al. The utility of basal cell-specific anti-cytokeratin antibody (34betaE12) in the diagnosis of prostate cancer. A review of 228 cases. Am J Surg Pathol 1995; 19:251-60. 5. Moinfar, F et al. Use of keratin 35betaE12 as an adjunct in the diagnosis of mammary intraepithelial neoplasia-ductal type--benign and malignant intraductal proliferations. Am J Surg Pathol 1999; 23:1048-58. 6. Yang, XJ et al. Rare expression of high-molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer. Am J Surg Pathol 1999; 23:147-52

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