Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. CD43 antibody reacts with an antigen expressed by normal and neoplastic T cells and myeloid lineage cells. It strongly stains T cell in the interfollicular areas of normal lymphoid tissues. It recognizes a cell surface glycoprotein of 95/115/135kDa, identified as CD43. Epitope of Mab Bra7G is clearly different from that of Mab DF-T1, called b as opposed to a for DF-T1. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low grade lymphoma, rather than a B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors and diagnosis of lymphoma.
1. Stross et al. J Clin Pathol 42: 953, 1989.
2. Borche et al. Eur J Immunol 17: 1523, 1987.