Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. SOX-10 is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein. SOX-10 is expressed in melanocytic lineages and is a sensitive marker of melanoma for conventional and desmoplastic subtypes. In normal tissue, SOX-10 is expressed in melanocytes and myoepithelial cells. References 1. Rehberg, S, et al, Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox 10-mediated transactivation. Mol Cell Biol, 2002: 22-5826-34 2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. AM J Surg Pathol. 2008: 32:1291-8 3. Nielsen TQ, et al. Sox 10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012: 20:445-50 4. Miettinen M, et al. Sox10-a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 38-826-35