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p40+HMW, Clone ZR8+34bE12, 15mL

SKU #: QHD-MM400-15
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p40+HMW, Clone ZR8+34bE12, 15mL is available to buy in increments of 1
Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. p40 is an antibody that recognizes ∆Np63-a p63 isoform and it is highly specific for squamous/basal cells. It may be a valuable marker in detecting Squamous Cell Carcinoma where p63 is currently used. It recognizes the shortest variant of p53. p40 is superior in specificity to p63 because it does not label lung adenocarcinomas like p63 does, which eliminates the potential of misinterpreting a positive adenocarcinoma as a squamous cell carcinoma. Intended for in vitro diagnostic (IVD) use. Anti-Cytokeratin 34bE12 is an antibody to high molecular weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1, 5, 10, and 14 that are found in complex epithelia. Anti-cytokeratin 34bE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, and neural tumors are unreactive with this antibody with some exceptions. Anti-cytokeratin 34bE12 does label myoepithelial cells and has been shown to be useful in distinguishing prostatic adenocarcinoma from hyperplasia of the prostate. This antibody has also been useful in separating benign from malignant intraductal breast proliferations. References 1. Gown, AM et al. Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am J Pathol 1984; 114:309. 2. 2. O’Malley, FP et al. Usefulness of immunoperoxidase staining with high-molecular-weight cytokeratin in the differential diagnosis of small-acinar lesions of the prostate gland. Virch Arch A 1990; 417:191. 3. 3. Amin, MB. Analysis of cribriform morphology in prostatic neoplasia using antibody to high-molecular-weight cytokeratins. Arch Pathol Lab Med March 1994; 118:260-264. 4. 4. Wojno, KJ et al. The utility of basal cell-specific anti-cytokeratin antibody (34betaE12) in the diagnosis of prostate cancer. A review of 228 cases. Am J Surg Pathol 1995; 19:251-60. 5. Moinfar, F et al. Use of keratin 35betaE12 as an adjunct in the diagnosis of mammary intraepithelial neoplasia-ductal type--benign and malignant intraductal proliferations. Am J Surg Pathol 1999; 23:1048-58. 6. Yang, XJ et al. Rare expression of high-molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer. Am J Surg Pathol 1999; 23:147-52
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