Rabbit Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. CD4 is a glycoprotein found on the surface of immune cells, such as T helper cells, monocytes, macrophages, and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with antigen-presenting cells, and also interacts directly with MHC class II molecules of the surface of the antigen-presenting cells. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extra nodal NK/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory regions and malignant lymphomas. References i) Brady RI, et al.: Science 1993, 260:979-983 ii) Sattentau QI, et al: Cell 1988, 52:631-633 iii) Williamson SL, et al.: Am J Pathol 1998, 152-1421-1426 iv) Dabbs DJ. Diagnostic Immunohistochemistry 2010; Churchill Livingstone