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MSH2, Clone G219-1129

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Grouped product items
Product Name Qty
MSH2, Clone G219-1129, 15mL
SKU #: QHD-MM152-15 EA
MSH2, Clone G219-1129, 7mL
SKU #: QHD-MM152-7 EA
MSH2, Clone G219-1129 is available to buy in increments of 1

Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. MSH2 is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite unstable. References 1. Pat T, et al. Cancer. 2008; 113-733-42 2. Bruecki WM, et al Anticancer Res. 2003:23:1773-8 3. Rigau V, et al. Arch Pathol Lab Med. 2003: 127-694-700. 4. Renkonen E, et al. J. Clin Oncol. 2003; 21-3629-37 5. Hoedema R, et al. Am Surg 2003: 69-387-92 6. Christensen M, et al. Cancer 2002, 95:2422-30

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