Cytokeratin, Clone AE1/AE3
Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. This antibody is a broad-spectrum keratin antibody cocktail composed of AE1 that recognizes acidic type I keratins 10, 14, 15, 16, 19, and AE3 that recognizes basic type II keratins 1, 2, 3, 4, 5, 6, 7, and 8. This antibody detects carcinomas of different organ origin and is useful in the classification of tumors of epithelial origin and undifferentiated carcinomas. References 1. Battifora H. Clinical applications of the immunohistochemistry of filamentous proteins. Am J Surg Pathol. 1988; 12:24. 2. Cooper D, et al. Classification of human epithelia and their neoplasms using monoclonalantibodies to keratins: strategies, applications, and limitations. Lab Invest. 1985; 52:243-56. 3. Gown AM, et al. Monoclonal antibodies to human intermediate filament proteins. III.Analysis of tumors. AM J Clin Pathol. 1985; 84:413. 4. Kriho UK, et al. Keratin expression in astrocytomas: An immunofluorescent andbiochemical reassessment. Virehows Arch. 1997; 431:139-47.