Cyclin E Protein, Clone HE12
Mouse Monoclonal. Intended for in vitro diagnostic (IVD) use. This antibody recognizes a doublet of 50 kDa and a single band of 42 kDa identified as Cyclin E. Cyclin proteins are a family of related proteins, which control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and is modulated by the presence of tumor suppressor proteins such as p16. References 1. Dulic et al. Science 257:1958, 1992. 2. Dutta et al. Proc. Natl. Acad. Sci. USA, 92:5386, 1995. 3. Faha et al, J Virol 67: 2456, 1993. 4. Gong et al. Cell Proliferation 28:1, 1995. 5. Koff et al. Cell 66:1217, 1991. 6. Ohtsubo et al. Mol Cell Biol 15: 2612, 1995.