Mouse Monoclonal, RTU. Intended for in vitro diagnostic (IVD) use. Tyrosinase is an enzyme involved in the biosynthesis of melanin. It is localized to melanocytes that can be found on the dermal/epidermal junction of normal skin and is not detected in other normal cells. It is a sensitive marker for melanocytic differentiation and has been found to be quite specific for melanotic lesions, such as malignant melanoma. References 1. Jungbluth AA, et al. T311--an anti-tyrosinase monoclonal antibody for the detection of melanocytic lesions in paraffin embedded tissues. Pathol Res Pract. 2000; 196:235-42. 2. Ordóñez NG. Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update. Hum Pathol. 2014; 45:191-205 3. Jaanson N, et al. Identification of the immunodominant regions of the melanoma antigen tyrosinase by anti-tyrosinase monoclonal antibodies. Melanoma Res. 2003. 13:473-82.