Calcitonin (P), 10mL

SKU #: RP04-10
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Rabbit Polyclonal, RTU. Intended for in vitro diagnostic (IVD) use. Immunohistochemical staining with anti-Calcitonin is an effective way of demonstrating calcitonin-producing parafollicular C-cells in the thyroid. IHC studies of C-cell hyperplasia and medullary thyroid carcinomas will predominantly stain positive for calcitonin. Other tissues such as lung and intestinal tract can also synthesize calcitonin. Expression of calcitonin in non-neoplastic and neoplastic neuroendocrine cells of these organs, such as carcinoids and small cell lung carcinomas, may be seen. References 1. Matias-Guiu X, et al. Medullary thyroid carcinoma: a 25-year perspective. Endocr Pathol. 2014; 25:21-9. 2. Fisher S, et al. Application of immunohistochemistry to thyroid neoplasms. Arch Pathol Lab Med. 2008; 132:359-72. 3. Tsutsumi Y. Immunohistochemical analysis of calcitonin and calcitonin gene-related peptide in human lung. Hum Pathol.1989; 20:869-902.

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