Mouse Monoclonal. Intended for in vitro diagnostic (IVD) use. This antibody reacts with a 220 kDa protein. CD15 plays a role in mediating ph phagocytosis, bactericidal activity and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is also expressed in Reed-Sterberg cells and some epithelial cells. CD15 is very useful in the identification of Hodgkin disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes. References 1. Hanjan et al. Clin Immuno Immunopathol 23: 172, 1982. 2. Hsu et al. Amer J Clin Pathol 82: 29, 1984. 3. Pinkus et al. Am J Pathol 119: 244, 1985.