Androgen Receptor (AR), Clone AR 441
Mouse Monoclonal. Intended for in vitro diagnostic (IVD) use. This antibody is specific to a protein of 110 kDa, identified as androgen receptor. It reacts with full length AR and also with the newly described A form of the receptor. The antibody does not cross-react with estrogen, progesterone or glucocorticoid receptors. Androgen receptor expression is broadly distributed in a variety of normal tissue types as well as in carcinomas of the breast and uroepithelium, and plays a critical role in prostate development, homeostasis, and carcinogenesis. References 1. Collins LC, et al. Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses’ Health Study. Mod Pathol. 2011; 24:924-31. 2. Rahmani AH, et al. Implication of androgen receptor in urinary bladder cancer: a critical mini review. Int J Mol Epidemiol Genet. 2013; 4:150-55. 3. Leach DA, et al. Stromal Androgen Receptor in Prostate Cancer Development and Progression. Cancers (Basel). 2017; 9:pii:E10.